AUNIP Gene Summary [Human]
Enables damaged DNA binding activity. Involved in double-strand break repair via homologous recombination; negative regulation of double-strand break repair via nonhomologous end joining; and spindle organization. Located in centrosome; site of DNA damage; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | AUNIP |
| Official Name | aurora kinase A and ninein interacting protein [Source:HGNC Symbol;Acc:HGNC:28363] |
| Ensembl ID | ENSG00000127423 |
| Bio databases IDs | |
| Aliases | aurora kinase A and ninein interacting protein |
| Synonyms | 2610002D18Rik, AIBP, aurora kinase A and ninein interacting protein, C1orf135, Clhc1, LOC683729 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AUNIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- damaged DNA binding
- Aurora kinase A and ninein interacting protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AUNIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle organization
- negative regulation of double-strand break repair via nonhomologous end joining
- double-strand break repair via homologous recombination
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- spindle pole
Molecular Function
What the gene product does at the molecular level
- protein binding
- damaged DNA binding