FOSL1 Gene Summary [Human]
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | FOSL1 |
| Official Name | FOS like 1, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:13718] |
| Ensembl ID | ENSG00000175592 |
| Bio databases IDs | |
| Aliases | FOS like 1, AP-1 transcription factor subunit |
| Synonyms | FOS like 1, AP-1 transcription factor subunit, fos-like antigen 1, FRA, FRA1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOSL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- Basic region leucine zipper
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic helix-loop-helix-leucine zipper domain
- double-stranded DNA binding
- bZIP
- transcription factor activity
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the FOSL1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metabolic syndrome X
- interstitial lung disease
- metastasis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- atherosclerosis
- asthma
- mammary neoplasm
- dextran sodium sulfate-induced colitis
role in cell
- expression in
- adhesion
- proliferation
- apoptosis
- cell viability
- quantity
- differentiation
- binding in
- growth
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- presynaptic membrane
- nucleoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOSL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vitellogenesis
- negative regulation of cell proliferation
- response to progesterone stimulus
- positive regulation of cell proliferation
- response to wounding
- positive regulation of cell cycle
- response to cAMP
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- learning
- response to virus
- response to mechanical stimulus
- chemotaxis
- response to gravity
- inflammatory response
- in utero embryonic development
- cytokine-mediated signaling pathway
- placenta blood vessel development
- female pregnancy
- response to hydrogen peroxide
- regulation of transcription from RNA polymerase II promoter
- toll-like receptor signaling pathway
- cellular defense response
- response to corticosterone stimulus
- positive regulation of apoptotic process
- gene expression
- positive regulation of transcription initiation, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity