PDCD1LG2 Gene Summary [Human]
Involved in negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; and negative regulation of interleukin-10 production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PDCD1LG2 |
| Official Name | programmed cell death 1 ligand 2 [Source:HGNC Symbol;Acc:HGNC:18731] |
| Ensembl ID | ENSG00000197646 |
| Bio databases IDs | |
| Aliases | programmed cell death 1 ligand 2, B7 dendritic cell molecule |
| Synonyms | B7-DC, bA574F11.2, Btdc, CD273, F730015O22Rik, PDCD1L2, PD-L2, programmed cell death 1 ligand 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDCD1LG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- Immunoglobulin like
- enzyme
- protein binding
- Ig-like V domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- neoplasia
- Alzheimer disease
- experimental autoimmune encephalomyelitis
- obesity
- inflammatory bowel disease
- organismal death
- polycystic ovary syndrome
- primary mediastinal large B-cell lymphoma
- primary cancer
role in cell
- expression in
- number
- quantity
- production in
- proliferation
- apoptosis
- activation
- induction in
- priming
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDCD1LG2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- cellular response to lipopolysaccharide
- T cell costimulation
- negative regulation of interleukin-10 production
- negative regulation of T cell proliferation
- adaptive immune response
- negative regulation of activated T cell proliferation
- cell surface receptor signaling pathway
- positive regulation of T cell proliferation
- negative regulation of interferon-gamma production
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- endomembrane system
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding