MCHR1 Gene Summary [Human]
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MCHR1 |
| Official Name | melanin concentrating hormone receptor 1 [Source:HGNC Symbol;Acc:HGNC:4479] |
| Ensembl ID | ENSG00000128285 |
| Bio databases IDs | |
| Aliases | melanin concentrating hormone receptor 1 |
| Synonyms | AW049955, GPR24, Mch1, MCH-1R, Mchr, melanin-concentrating hormone receptor 1, SLC-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MCHR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- hormone binding
- Cholecystokinin A receptor, N-terminal
- neuropeptide receptor
- 7 transmembrane receptor (rhodopsin family)
- melanin-concentrating hormone receptor
- protein binding
- receptor binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the MCHR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperphagia
- weight gain
- obesity
- osteoporosis
- weight loss
- early-onset obesity
- experimentally-induced diabetes
role in cell
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- non-motile cilium
- cilia
- cellular membrane
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MCHR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- neuropeptide signaling pathway
- generation of precursor metabolites and energy
- G-protein coupled receptor signaling pathway
- positive regulation of calcium ion transport
- feeding behavior
- cell surface receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- cilium
- cilium membrane
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuropeptide binding
- neuropeptide receptor activity
- melanin-concentrating hormone receptor activity
- hormone binding
- receptor binding