Mchr1 Gene Summary [Mouse]
Enables signaling receptor binding activity. Predicted to be involved in several processes, including neuropeptide signaling pathway; positive regulation of calcium ion transport; and positive regulation of cytosolic calcium ion concentration. Located in ciliary membrane; neuron projection; and non-motile cilium. Is expressed in brain and lung. Human ortholog(s) of this gene implicated in morbid obesity. Orthologous to human MCHR1 (melanin concentrating hormone receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mchr1 |
| Official Name | melanin-concentrating hormone receptor 1 [Source:MGI Symbol;Acc:MGI:2180756] |
| Ensembl ID | ENSMUSG00000050164 |
| Bio databases IDs | |
| Aliases | melanin-concentrating hormone receptor 1 |
| Synonyms | AW049955, GPR24, Mch1, MCH-1R, Mchr, melanin-concentrating hormone receptor 1, SLC-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mchr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- hormone binding
- Cholecystokinin A receptor, N-terminal
- neuropeptide receptor
- 7 transmembrane receptor (rhodopsin family)
- melanin-concentrating hormone receptor
- protein binding
- receptor binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Mchr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperphagia
- weight gain
- obesity
- osteoporosis
- weight loss
- early-onset obesity
- experimentally-induced diabetes
phenotypes
- abnormal circadian temperature homeostasis
- abnormal energy expenditure
- abnormal frequency of paradoxical sleep
- abnormal hormone level
- abnormal metabolism
- abnormal nervous system electrophysiology
- abnormal passive avoidance behavior
- abnormal sleep pattern
- abnormal social investigation
- decreased anxiety-related response
- decreased body weight
- decreased circulating insulin level
- decreased circulating leptin level
- decreased compact bone mass
- decreased compact bone thickness
- decreased percent body fat/body weight
- decreased respiratory quotient
- decreased response to stress-induced hyperthermia
- decreased serotonin level
- decreased susceptibility to diet-induced obesity
- decreased thyroxine level
- decreased total body fat amount
- hyperactivity
- impaired behavioral response to xenobiotic
- increased body temperature
- increased circulating corticosterone level
- increased circulating type I collagen C-terminal telopeptide level
- increased fluid intake
- increased food intake
- increased heart rate
- increased lean body mass
- osteoporosis
- polyphagia
- slow postnatal weight gain
- weight loss
role in cell
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- non-motile cilium
- cilia
- cellular membrane
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mchr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- neuropeptide signaling pathway
- generation of precursor metabolites and energy
- G-protein coupled receptor signaling pathway
- positive regulation of calcium ion transport
- feeding behavior
- cell surface receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- cilium
- cilium membrane
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuropeptide binding
- neuropeptide receptor activity
- melanin-concentrating hormone receptor activity
- hormone binding
- receptor binding