EMC4 Gene Summary [Human]
Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EMC4 |
| Official Name | ER membrane protein complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:28032] |
| Ensembl ID | ENSG00000128463 |
| Bio databases IDs | |
| Aliases | ER membrane protein complex subunit 4 |
| Synonyms | 2610318K02Rik, ER membrane protein complex subunit 4, PIG17, RGD1310905, TMEM85 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EMC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF1077)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EMC4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein insertion into ER membrane by stop-transfer membrane-anchor sequence
- tail-anchored membrane protein insertion into ER membrane
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- ER membrane protein complex
Molecular Function
What the gene product does at the molecular level
- membrane insertase activity
- protein binding