EIF2AK4 Gene Summary [Human]
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
Details
| Type | Protein Coding |
| Official Symbol | EIF2AK4 |
| Official Name | eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:HGNC:19687] |
| Ensembl ID | ENSG00000128829 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 2 alpha kinase 4, eIF-2-alpha kinase |
| Synonyms | 2610011M03, eukaryotic translation initiation factor 2 alpha kinase 4, eukaryotic translation initiation factor 2 α kinase 4, GCN2, MGCN2, PVOD2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF2AK4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- HGTP_anticodon
- protein serine/threonine kinase
- class_II_aaRS-like_core
- eukaryotic translation initiation factor 2alpha kinase
- ATP phosphoribosyltransferase, regulatory subunit
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- RWD, DRWD, and ELF domain family
- RWD domain
- Anticodon binding domain of tRNAs
Pathways
Biological processes and signaling networks where the EIF2AK4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- hypertension
- insulin resistance
- hepatic steatosis
- hypoglycemia
- glioblastoma
- glioblastoma cancer
- fibrosis
- pulmonary venoocclusive disease type 2
- familial hemophagocytic lymphohistiocytosis
role in cell
- proliferation
- function
- cell death
- expression in
- activation in
- phosphorylation in
- growth
- quantity
- cell viability
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF2AK4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translational initiation
- negative regulation of CREB transcription factor activity
- positive regulation of long-term synaptic potentiation
- cellular response to amino acid starvation
- negative regulation of neuron differentiation
- adaptive immune response
- protein autophosphorylation
- positive regulation of defense response to virus by host
- learning
- T cell activation involved in immune response
- regulation of translational initiation
- protein phosphorylation
- viral protein biosynthetic process
- regulation of feeding behavior
- long-term memory
- DNA damage checkpoint
- positive regulation of adaptive immune response
- positive regulation of translational initiation in response to starvation
- cellular response to UV
- defense response to virus
- regulation of translational initiation by eIF2 alpha phosphorylation
- negative regulation of translational initiation in response to stress
- cellular response to cold
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- eukaryotic translation initiation factor 2alpha kinase activity
- tRNA binding
- protein serine/threonine kinase activity