ICE1 Gene Summary [Human]
Enables protein-macromolecule adaptor activity. Involved in several processes, including positive regulation of intracellular protein transport; positive regulation of transcription by RNA polymerase III; and snRNA transcription. Located in Cajal body; histone locus body; and transcriptionally active chromatin. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ICE1 |
| Official Name | interactor of little elongation complex ELL subunit 1 [Source:HGNC Symbol;Acc:HGNC:29154] |
| Ensembl ID | ENSG00000164151 |
| Bio databases IDs | |
| Aliases | interactor of little elongation complex ELL subunit 1 |
| Synonyms | BC018507, C77245, interactor of little elongation complex ELL subunit 1, KIAA0947, mKIAA0947, RGD1309747 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ICE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
- Cajal bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ICE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of intracellular protein transport
- snRNA transcription from RNA polymerase II promoter
- snRNA transcription from RNA polymerase III promoter
- positive regulation of transcription from RNA polymerase III promoter
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- histone locus body
- euchromatin
- nuclear body
- transcription elongation factor complex
- Cajal body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding, bridging