ARPP19 Gene Summary [Human]
The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | ARPP19 |
| Official Name | cAMP regulated phosphoprotein 19 [Source:HGNC Symbol;Acc:HGNC:16967] |
| Ensembl ID | ENSG00000128989 |
| Bio databases IDs | |
| Aliases | cAMP regulated phosphoprotein 19, endosulfine alpha-like |
| Synonyms | 2700024H10Rik, Arpp12, ARPP-16, cAMP-regulated phosphoprotein 19, Cyclic AMP phosphoprotein, 19 kD, ENSAL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARPP19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- phosphatase inhibitor
- cAMP-regulated phosphoprotein/endosulfine conserved region
- protein phosphatase binding
- potassium channel regulator
- protein phosphatase regulator
- protein binding
- receptor binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- synapse
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARPP19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- G2/M transition of mitotic cell cycle
- positive regulation of glucose import
- negative regulation of protein dephosphorylation
- positive regulation of gluconeogenesis
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- protein binding
- phosphatase inhibitor activity
- receptor binding
- potassium channel regulator activity
- protein phosphatase 2A binding
- protein phosphatase regulator activity