GSTP1 Gene Summary [Human]
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GSTP1 |
| Official Name | glutathione S-transferase pi 1 [Source:HGNC Symbol;Acc:HGNC:4638] |
| Ensembl ID | ENSG00000084207 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase pi 1 |
| Synonyms | DFN7, FAEES3, GLUTATHIONE S TRANSFERASE PHI, glutathione S-transferase pi 1, GST3, Gst7-7, Gst7pi, GST Acidic Form, GST-P, GST P1-1, Gstp2, GST PI, Gst pi-class subunit 7, Gst Yf, HEL-S-22, PI |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GSTP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- protein kinase binding
- fatty acid binding
- kinase regulator
- JUN kinase binding
- enzyme
- protein binding
- protein serine/threonine kinase inhibitor
- binding protein
- glutathione transferase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- glutathione peroxidase
- toxin binding
Pathways
Biological processes and signaling networks where the GSTP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- adenoma formation
- psoriasis
- prostate cancer
- liver cancer
- eczema
- chronic obstructive pulmonary disease
- hematological toxicity
role in cell
- expression in
- phosphorylation in
- cell viability
- apoptosis
- binding in
- proliferation
- activation in
- cell death
- survival
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane vesicles
- soluble fraction
- insoluble fractions
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GSTP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAP kinase activity
- negative regulation of MAPK cascade
- negative regulation of JUN kinase activity
- negative regulation of interleukin-1 beta production
- negative regulation of biosynthetic process
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of protein kinase activity
- hepoxilin biosynthetic process
- negative regulation of fibroblast proliferation
- negative regulation of leukocyte proliferation
- negative regulation of monocyte chemotactic protein-1 production
- nitric oxide storage
- negative regulation of tumor necrosis factor production
- linoleic acid metabolic process
- prostaglandin metabolic process
- response to reactive oxygen species
- negative regulation of acute inflammatory response
- regulation of ERK1 and ERK2 cascade
- central nervous system development
- cellular response to lipopolysaccharide
- negative regulation of nitric-oxide synthase biosynthetic process
- glutathione metabolic process
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of apoptotic process
- negative regulation of ERK1 and ERK2 cascade
- xenobiotic metabolic process
- regulation of stress-activated MAPK cascade
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of stress-activated MAPK cascade
- common myeloid progenitor cell proliferation
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- TRAF2-GSTP1 complex
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- vesicle
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- fatty acid binding
- protein binding
- glutathione peroxidase activity
- glutathione transferase activity
- JUN kinase binding
- nitric oxide binding
- S-nitrosoglutathione binding
- dinitrosyl-iron complex binding
- kinase regulator activity