NFE2L3 Gene Summary [Human]
This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]
Details
| Type | Protein Coding |
| Official Symbol | NFE2L3 |
| Official Name | nuclear factor, erythroid 2 like 3 [Source:HGNC Symbol;Acc:HGNC:7783] |
| Ensembl ID | ENSG00000050344 |
| Bio databases IDs | |
| Aliases | nuclear factor, erythroid 2 like 3, NFE2 like bZIP transcription factor 3 |
| Synonyms | LOC102557123, NFE2 like bZIP transcription factor 3, NFE2-RELATED FACTOR1, NRF3, Nuclear factor, erythroid derived 2, like 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFE2L3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- DNA binding domain
- nucleic acid binding
- transcription activation domain
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- heterodimerization domain
- bZIP
- transcription factor activity
- basic region leucin zipper
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- cervical cancer
- colorectal adenocarcinoma
- rectum cancer
- gastric adenocarcinoma
- pancreatic adenocarcinoma
- colorectal carcinomagenesis
- colorectal neoplasia
- epithelial neoplasia
role in cell
- activation in
- expression in
- proliferation
- apoptosis
- growth
- invasion by
- migration
- cell viability
- cell cycle progression
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Endoplasmic Reticulum
- nucleoplasm
- nuclear envelope
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFE2L3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity