DAD1 Gene Summary [Human]
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | DAD1 |
| Official Name | defender against cell death 1 [Source:HGNC Symbol;Acc:HGNC:2664] |
| Ensembl ID | ENSG00000129562 |
| Bio databases IDs | |
| Aliases | defender against cell death 1, oligosaccharyltransferase 2 homolog (S. cerevisiae), oligosaccharyltransferase subunit 2 (non-catalytic), Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 |
| Synonyms | defender against cell death 1, LOC100044173, OST2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DAD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DAD family
- enzyme activator activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- epithelial cancer
- chronic lymphocytic leukemia
- Down syndrome
- renal clear cell adenocarcinoma
- renal clear cell cancer
- syndactyly
- Crohn disease
- urothelial carcinoma
- urothelial cancer
regulates
- asparagine
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DAD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- negative regulation of apoptotic process
- blastocyst development
- apoptotic process
- protein glycosylation
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- oligosaccharyltransferase complex
- membrane
Molecular Function
What the gene product does at the molecular level
- enzyme activator activity