Dad1 Gene Summary [Mouse]
Predicted to enable enzyme activator activity. Acts upstream of or within blastocyst development and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human DAD1 (defender against cell death 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dad1 |
| Official Name | defender against cell death 1 [Source:MGI Symbol;Acc:MGI:101912] |
| Ensembl ID | ENSMUSG00000022174 |
| Bio databases IDs | |
| Aliases | defender against cell death 1 |
| Synonyms | defender against cell death 1, LOC100044173, OST2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dad1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DAD family
- enzyme activator activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- epithelial cancer
- chronic lymphocytic leukemia
- Down syndrome
- renal clear cell adenocarcinoma
- renal clear cell cancer
- syndactyly
- Crohn disease
- urothelial carcinoma
- urothelial cancer
regulates
- asparagine
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dad1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- negative regulation of apoptotic process
- blastocyst development
- apoptotic process
- protein glycosylation
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- oligosaccharyltransferase complex
- membrane
Molecular Function
What the gene product does at the molecular level
- enzyme activator activity