MAP1S Gene Summary [Human]
Enables DNA binding activity and cytoskeletal protein binding activity. Involved in microtubule bundle formation; neuron projection morphogenesis; and regulation of chromatin disassembly. Located in several cellular components, including microtubule cytoskeleton; nuclear lumen; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MAP1S |
| Official Name | microtubule associated protein 1S [Source:HGNC Symbol;Acc:HGNC:15715] |
| Ensembl ID | ENSG00000130479 |
| Bio databases IDs | |
| Aliases | microtubule associated protein 1S |
| Synonyms | 6430517J16Rik, BPY2IP1, C19orf5, MAP8, microtubule-associated protein 1S, Mtap1s, VCY2IP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP1S often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- actin filament binding
- microtubule binding
- microtubule binding domain
- tubulin binding
- enzyme
- protein binding
- identical protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- coronary artery disease
- myocardial infarction
- osteonecrosis
role in cell
- apoptosis
- formation
- morphogenesis
- stabilization
- mitosis
- prometaphase
- phagocytosis by
- abnormal morphology
- autophagy by
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cell junction
- spindle apparatus
- perinuclear region
- Nucleus
- centrosome
- microtubules
- microtubule organizing centers
- cytosol
- nucleoplasm
- nucleoli
- spindle fibers
- synapse
- cellular protrusions
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP1S gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic spindle organization
- nervous system development
- neuron projection morphogenesis
- microtubule cytoskeleton organization
- brain development
- metaphase plate congression
- microtubule bundle formation
- mitochondrion transport along microtubule
- axonogenesis
- autophagy
- apoptotic process
- microtubule anchoring at centrosome
- regulation of microtubule depolymerization
- dendrite development
Cellular Component
Where in the cell the gene product is active
- synapse
- neuronal cell body
- nucleolus
- cell projection
- microtubule associated complex
- nucleoplasm
- microtubule
- nucleus
- dendrite
- centrosome
- perinuclear region of cytoplasm
- microtubule organizing center
- spindle
- cell junction
- cytosol
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- DNA binding
- tubulin binding
- identical protein binding
- deoxyribonuclease activity
- protein binding
- actin binding
- beta-tubulin binding
- microtubule binding