KPNB1 Gene Summary [Human]
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Details
| Type | Protein Coding |
| Official Symbol | KPNB1 |
| Official Name | karyopherin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6400] |
| Ensembl ID | ENSG00000108424 |
| Bio databases IDs | |
| Aliases | karyopherin subunit beta 1, importin 1 |
| Synonyms | IMB1, Imp beta 1, Impnb, IMPORTIN 90, Importin Beta 1, Importin β, Importin β 1, Imp β 1, IPO1, IPOB, karyopherin subunit beta 1, karyopherin subunit β 1, Karyopherin β 1, NTF97, Nuclear factor P97, p97, Ptac97 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KPNB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT repeat
- binding protein
- HEAT-like repeat
- zinc ion binding
- heat shock protein binding
- enzyme binding
- protein domain specific binding
- Importin-beta N-terminal domain
- protein binding
- nuclear localization sequence binding
- kinesin binding
- Ran binding domain
Pathways
Biological processes and signaling networks where the KPNB1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- melanoma
- melanoma cancer
- metastasis
- neoplasia
- organismal death
- myopathy
- psoriasis
- spinocerebellar ataxia type 3
- mucopolysaccharidosis type IVB
- NPM1 mutation positive acute myeloid leukemia
role in cell
- accumulation in
- expression in
- phosphorylation in
- apoptosis
- migration
- invasion by
- colony formation
- binding
- proliferation
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- detergent resistant lipid raft fraction
- endoplasmic reticulum tubules
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- Extracellular Space
- perinuclear region
- Mitochondria
- cytosol
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- nuclear envelope
- stress granule
- perikaryon
- detergent-soluble fraction
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KPNB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astral microtubule organization
- RNA import into nucleus
- establishment of mitotic spindle localization
- protein import into nucleus
- NLS-bearing substrate import into nucleus
- mitotic chromosome movement towards spindle pole
- mitotic metaphase plate congression
- spindle assembly involved in mitosis
- ribosomal protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- specific granule lumen
- NLS-dependent protein nuclear import complex
- extracellular region
- nuclear pore
- nucleoplasm
- nuclear envelope
- nucleus
- nuclear membrane
- extracellular vesicular exosome
- cytoplasm
- membrane
- endoplasmic reticulum tubular network
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein domain specific binding
- RNA binding
- protein binding
- small GTPase binding
- Hsp90 protein binding
- nuclear localization sequence binding
- enzyme binding