JUND Gene Summary [Human]
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]
Details
| Type | Protein Coding |
| Official Symbol | JUND |
| Official Name | JunD proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6206] |
| Ensembl ID | ENSG00000130522 |
| Bio databases IDs | |
| Aliases | JunD proto-oncogene, AP-1 transcription factor subunit, transcription factor jun-D, JunD-FL isoform, activator protein 1 |
| Synonyms | AP-1, JUND1, jun D proto-oncogene, JunD proto-oncogene, AP-1 transcription factor subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human JUND often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- ligand-dependent nuclear receptor interactor
- dimerization domain
- transcription co-activator
- nucleic acid binding
- transcription activation domain
- heparin binding domain
- enzyme binding
- Basic region leucine zipper
- transcription factor binding
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- basic domain
- bZIP
- transcription factor activity
- basic region leucin zipper
- Jun-like transcription factor
Pathways
Biological processes and signaling networks where the JUND gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- psoriasis
- Down syndrome
- fibrosis
- dilated cardiomyopathy
- glomerulosclerosis
- muscular hypertrophy
role in cell
- apoptosis
- expression in
- upregulation in
- proliferation
- transactivation in
- transformation
- growth
- colony formation
- response
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human JUND gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to calcium ion
- gene expression
- regulation of cell cycle
- osteoblast development
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- transcriptional repressor complex
- AP1 complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- transcription factor binding
- enzyme binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity