ATF7 Gene Summary [Human]
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ATF7 |
| Official Name | activating transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:792] |
| Ensembl ID | ENSG00000170653 |
| Bio databases IDs | |
| Aliases | activating transcription factor 7 |
| Synonyms | 1110012F10RIK, 9430065F09RIK, activating transcription factor 7, AI549878, ATFA, ATFA2, C130020M04RIK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATF7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- protein kinase binding
- nucleic acid binding
- enzyme binding
- Basic region leucine zipper
- transcription factor binding
- protein binding
- zinc binding domain
- sequence-specific DNA binding
- JNK2-binding domain
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- basic helix-loop-helix-leucine zipper domain
- double-stranded DNA binding
- zinc finger domain
- bZIP
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the ATF7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoplasia
- anemia
- lymphomagenesis
- growth failure
- chronic pancreatitis
- hemopericardium
role in cell
- proliferation
- apoptosis
- expression in
- differentiation
- molecular cleavage in
- transactivation in
- binding in
- phosphorylation in
- abnormal morphology
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATF7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- cAMP response element binding
- protein binding
- metal ion binding
- transcription regulatory region sequence-specific DNA binding
- mitogen-activated protein kinase binding
- transcription coactivator binding
- enzyme binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity