JUNB Gene Summary [Human]
Enables sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription factor AP-1 complex. Biomarker of Hodgkin's lymphoma and anaplastic large cell lymphoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | JUNB |
| Official Name | JunB proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6205] |
| Ensembl ID | ENSG00000171223 |
| Bio databases IDs | |
| Aliases | JunB proto-oncogene, AP-1 transcription factor subunit |
| Synonyms | AP-1, Jun-B oncogene, jun B proto-oncogene, JunB proto-oncogene, AP-1 transcription factor subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human JUNB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- dimerization domain
- Sumoylation motif
- transcription factor binding domain
- DNA binding domain
- nucleic acid binding
- Basic region leucine zipper
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- bZIP
- delta-like domain
- transcription factor activity
- basic region leucin zipper
- Jun-like transcription factor
Pathways
Biological processes and signaling networks where the JUNB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- skin cancer
- breast cancer
- acute myeloid leukemia
- cervical cancer
- COVID-19
- organismal death
- psoriasis
- metastasis
role in cell
- phosphorylation in
- activation in
- apoptosis
- quantity
- production in
- expression in
- proliferation
- formation in
- differentiation
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Mitochondria
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human JUNB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell differentiation
- decidualization
- vasculogenesis
- positive regulation of transcription from RNA polymerase II promoter
- embryonic process involved in female pregnancy
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- osteoclast proliferation
- regulation of T-helper 17 cell differentiation
- osteoclast differentiation
- cellular response to calcium ion
- labyrinthine layer blood vessel development
- osteoblast proliferation
- osteoblast differentiation
- regulation of cell cycle
- trophectodermal cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- AP1 complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- transcription factor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity