TRPM4 Gene Summary [Human]
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | TRPM4 |
| Official Name | transient receptor potential cation channel subfamily M member 4 [Source:HGNC Symbol;Acc:HGNC:17993] |
| Ensembl ID | ENSG00000130529 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel subfamily M member 4 |
| Synonyms | 1110030C19Rik, EKVP6, HBN1, hTRPM4, LTRPC4, MLS2S, PFHB1B, Riken cDNA 1110030c19, transient receptor potential cation channel subfamily M member 4, transient receptor potential cation channel, subfamily M, member 4, TRPM4B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRPM4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium activated cation channel
- sodium channel
- SLOG in TRPM
- calcium channel
- ATP binding
- calcium ion binding
- protein binding
- identical protein binding
- voltage-gated ion channel
- ion channel
Pathways
Biological processes and signaling networks where the TRPM4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- progressive familial heart block type IB
- breast cancer
- cerebral edema
- organismal death
- passive cutaneous anaphylaxis
- metastasis
- psoriasiform dermatitis
- erythrokeratodermia variabilis et progressiva 6
role in cell
- phosphorylation in
- function
- proliferation
- differentiation
- cell death
- migration
- quantity
- transmembrane potential
- chemotaxis
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- nucleoplasm
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRPM4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- membrane depolarization involved in regulation of Purkinje myocyte cell action potential
- membrane depolarization involved in regulation of AV node cardiac muscle cell action potential
- protein sumoylation
- membrane depolarization involved in regulation of bundle of His cardiac muscle cell action potential
- positive regulation of vasoconstriction
- positive regulation of cell proliferation
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of fat cell differentiation
- adaptive immune response
- negative regulation of osteoblast differentiation
- elevation of cytosolic calcium ion concentration
- negative regulation of bone mineralization
- protein homotetramerization
- regulation of T cell cytokine production
- dendritic cell chemotaxis
- calcium ion transmembrane transport
- regulation of heart rate by cardiac conduction
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- cellular response to ATP
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- sodium channel complex
- membrane
- cytosol
- endoplasmic reticulum
- Golgi apparatus
- neuronal cell body
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calcium activated cation channel activity
- calmodulin binding
- protein binding
- calcium ion binding
- sodium channel activity