GATA5 Gene Summary [Human]
The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GATA5 |
| Official Name | GATA binding protein 5 [Source:HGNC Symbol;Acc:HGNC:15802] |
| Ensembl ID | ENSG00000130700 |
| Bio databases IDs | |
| Aliases | GATA binding protein 5 |
| Synonyms | bB379O24.1, CHTD5, GATA binding protein 5, GATAS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GATA5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- nucleic acid binding
- protein binding
- GATA-type transcription activator, N-terminal
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- zinc finger binding to DNA consensus sequence [AT]GATA[AG]
- zinc finger domain
- basic domain
- transcription factor activity
- ZnF_GATA
Pathways
Biological processes and signaling networks where the GATA5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- hypertension
- prostate cancer
- multiple types congenital heart defects type 5
- chronic obstructive pulmonary disease
- bicuspid aortic valve
- perivascular fibrosis
- glomerulosclerosis
- benign prostatic hyperplasia
- lower urinary tract symptom
role in cell
- phosphorylation in
- expression in
- cell viability
- proliferation
- activation in
- migration
- apoptosis
- invasion by
- transactivation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GATA5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intestinal epithelial cell differentiation
- aortic valve morphogenesis
- endocardial cushion fusion
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of Notch signaling pathway
- cardiac muscle tissue development
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- heart induction
- negative regulation of cardiac muscle hypertrophy
- cellular response to BMP stimulus
- positive regulation of gene expression
- cell fate commitment
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- zinc ion binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity