NPAS1 Gene Summary [Human]
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NPAS1 |
| Official Name | neuronal PAS domain protein 1 [Source:HGNC Symbol;Acc:HGNC:7894] |
| Ensembl ID | ENSG00000130751 |
| Bio databases IDs | |
| Aliases | neuronal PAS domain protein 1, neuronal PAS1, member of PAS superfamily 5 |
| Synonyms | bHLHe11, MOP5, neuronal PAS domain protein 1, PASD5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPAS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nuclear export signal
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- protein binding
- PAS fold
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription repression domain
- helix loop helix domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NPAS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- central nervous system development
- negative regulation of transcription, DNA-dependent
- startle response
- maternal behavior
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein heterodimerization activity
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity