SH3BGRL Gene Summary [Human]
Predicted to enable SH3 domain binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SH3BGRL |
| Official Name | SH3 domain binding glutamate rich protein like [Source:HGNC Symbol;Acc:HGNC:10823] |
| Ensembl ID | ENSG00000131171 |
| Bio databases IDs | |
| Aliases | SH3 domain binding glutamate rich protein like |
| Synonyms | 1190008F14Rik, HEL-S-115, RGD1560520, SH3BGR, Sh3bgrl1, SH3-binding domain glutamic acid-rich protein like, SH3 domain binding glutamate rich protein like, SH3 domain binding glutamate rich protein like 1, SH3L1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SH3BGRL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- metastasis
- Turner syndrome
- COVID-19
role in cell
- activation in
- phosphorylation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SH3BGRL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- SH3 domain binding