Sh3bgrl Gene Summary [Mouse]
Predicted to enable protein-RNA adaptor activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of cytoplasmic translational initiation and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in cerebral cortex and genitourinary system. Orthologous to human SH3BGRL (SH3 domain binding glutamate rich protein like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh3bgrl |
| Official Name | SH3-binding domain glutamic acid-rich protein like [Source:MGI Symbol;Acc:MGI:1930849] |
| Ensembl ID | ENSMUSG00000031246 |
| Bio databases IDs | |
| Aliases | SH3-binding domain glutamic acid-rich protein like |
| Synonyms | 1190008F14Rik, HEL-S-115, RGD1560520, SH3BGR, Sh3bgrl1, SH3-binding domain glutamic acid-rich protein like, SH3 domain binding glutamate rich protein like, SH3 domain binding glutamate rich protein like 1, SH3L1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sh3bgrl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- metastasis
- Turner syndrome
- COVID-19
role in cell
- activation in
- phosphorylation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sh3bgrl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- SH3 domain binding