AOC3 Gene Summary [Human]
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Details
| Type | Protein Coding |
| Official Symbol | AOC3 |
| Official Name | amine oxidase copper containing 3 [Source:HGNC Symbol;Acc:HGNC:550] |
| Ensembl ID | ENSG00000131471 |
| Bio databases IDs | |
| Aliases | amine oxidase copper containing 3, vascular adhesion protein 1 |
| Synonyms | amine oxidase copper containing 3, amine oxidase, copper containing 3, Carbazide-sensitive amine oxidase, HPAO, SSAO, VAP-1, vascular adhesion protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AOC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Copper amine oxidase, N3 domain
- quinone binding
- primary-amine oxidase
- amine oxidase
- calcium ion binding
- enzyme
- protein binding
- identical protein binding
- Copper amine oxidase, N2 domain
- integrin binding domain
- copper ion binding
- Copper amine oxidase, enzyme domain
- amine oxidase (copper-containing)
- protein heterodimerization
Pathways
Biological processes and signaling networks where the AOC3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congestive heart failure
- hypertension
- preeclampsia
- pregnancy-induced hypertension
- essential hypertension
- diabetes mellitus
- non-small cell lung cancer
- neoplasia
- cancer
- myocardial infarction
regulates
- histamine
- D-glucose
- Fibrinogen
- amine
- benzylamine
- primary amine
- methylamine
- PNAD
- hydrogen peroxide
- SELP
role in cell
- production in
- quantity
- adhesion
- migration
- binding
- number
- transmigration
- recruitment
- cell rolling
- homing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- caveolae-derived endocytic vesicles
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- lipid droplets
- caveolae
- early endosomes
- microvilli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AOC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- amine metabolic process
- response to antibiotic
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytoplasm
- microvillus
- membrane
- Golgi apparatus
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- copper ion binding
- quinone binding
- aliphatic-amine oxidase activity
- protein heterodimerization activity
- calcium ion binding
- primary amine oxidase activity