Aoc3 Gene Summary [Mouse]
Predicted to enable several functions, including identical protein binding activity; metal ion binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including eating behavior; leukocyte migration involved in inflammatory response; and positive regulation of D-glucose transmembrane transport. Predicted to be located in several cellular components, including cell surface; extracellular space; and microvillus. Predicted to be active in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; axial skeleton; cardiovascular system; sensory organ; and skin. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AOC3 (amine oxidase copper containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aoc3 |
| Official Name | amine oxidase, copper containing 3 [Source:MGI Symbol;Acc:MGI:1306797] |
| Ensembl ID | ENSMUSG00000019326 |
| Bio databases IDs | |
| Aliases | amine oxidase, copper containing 3 |
| Synonyms | amine oxidase copper containing 3, amine oxidase, copper containing 3, Carbazide-sensitive amine oxidase, HPAO, SSAO, VAP-1, vascular adhesion protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aoc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Copper amine oxidase, N3 domain
- quinone binding
- primary-amine oxidase
- amine oxidase
- calcium ion binding
- enzyme
- protein binding
- identical protein binding
- Copper amine oxidase, N2 domain
- integrin binding domain
- copper ion binding
- Copper amine oxidase, enzyme domain
- amine oxidase (copper-containing)
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Aoc3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congestive heart failure
- hypertension
- preeclampsia
- pregnancy-induced hypertension
- essential hypertension
- diabetes mellitus
- non-small cell lung cancer
- neoplasia
- cancer
- myocardial infarction
regulates
- histamine
- D-glucose
- Fibrinogen
- amine
- benzylamine
- primary amine
- methylamine
- PNAD
- hydrogen peroxide
- SELP
role in cell
- production in
- quantity
- adhesion
- migration
- binding
- number
- transmigration
- recruitment
- cell rolling
- homing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- caveolae-derived endocytic vesicles
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- lipid droplets
- caveolae
- early endosomes
- microvilli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aoc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- amine metabolic process
- response to antibiotic
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytoplasm
- microvillus
- membrane
- Golgi apparatus
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- copper ion binding
- quinone binding
- aliphatic-amine oxidase activity
- protein heterodimerization activity
- calcium ion binding
- primary amine oxidase activity