LMAN2 Gene Summary [Human]
This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | LMAN2 |
| Official Name | lectin, mannose binding 2 [Source:HGNC Symbol;Acc:HGNC:16986] |
| Ensembl ID | ENSG00000169223 |
| Bio databases IDs | |
| Aliases | lectin, mannose binding 2 |
| Synonyms | 1110003H06Rik, 1300009F09Rik, C5orf8, GP36B, GP36b glycoprotein, lectin, mannose-binding 2, VIP36 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LMAN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ectodomain
- heat shock protein binding
- legume lectins
- protein binding
- carbohydrate binding
- mannose binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- papillary thyroid carcinoma
- prostate cancer
- respiratory disorder
- papillary thyroid cancer
- small vessel disease stroke
- infection by HIV-1
regulates
- glycoprotein
role in cell
- phagocytosis
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- exocytic vesicle
- cell surface
- Extracellular Space
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- Mitochondria
- ER-to-Golgi intermediate compartment
- Golgi membrane
- cytoplasmic vesicles
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LMAN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- retrograde vesicle-mediated transport, Golgi to ER
- protein transport
- positive regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- extracellular vesicular exosome
- Golgi apparatus
- ER to Golgi transport vesicle
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- mannose binding
- protein binding
- metal ion binding
- carbohydrate binding