FBXW9 Gene Summary [Human]
Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | FBXW9 |
| Official Name | F-box and WD repeat domain containing 9 [Source:HGNC Symbol;Acc:HGNC:28136] |
| Ensembl ID | ENSG00000132004 |
| Bio databases IDs | |
| Aliases | F-box and WD repeat domain containing 9 |
| Synonyms | 1110017H11Rik, F-box and WD-40 domain protein 9, F-box and WD repeat domain containing 9, Fbw9, MEC-15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXW9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain superfamily
- WD40
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXW9 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding