HERC5 Gene Summary [Human]
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Aug 2021]
Details
| Type | Protein Coding |
| Official Symbol | HERC5 |
| Official Name | HECT and RLD domain containing E3 ubiquitin protein ligase 5 [Source:HGNC Symbol;Acc:HGNC:24368] |
| Ensembl ID | ENSG00000138646 |
| Bio databases IDs | |
| Aliases | HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
| Synonyms | 2510038N07RIK, CEB1, CEBP1, HECT and RLD domain containing E3 ubiquitin protein ligase 5, HECT domain and RID 5, Herc6, LOC51191 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HERC5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of chromosome condensation (RCC1) repeat
- HECTc
- regulation of chromosome condensation domain
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- ISG15 conjugating enzyme
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- systemic lupus erythematosus
- idiopathic inflammatory myopathy
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- systemic lupus erythematosus nephritis
- antineutrophil cytoplasmic antibody-associated vasculitis
- ATAD3A-related type I interferonopathy
- dermatomyositis
role in cell
- expression in
- production in
- conjugation in
- ubiquitination in
- isgylation in
- transactivation in
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HERC5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- innate immune response
- ISG15-protein conjugation
- defense response to virus
- regulation of defense response to virus
- regulation of cyclin-dependent protein kinase activity
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- RNA binding
- ISG15 ligase activity