CCT4 Gene Summary [Human]
The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | CCT4 |
| Official Name | chaperonin containing TCP1 subunit 4 [Source:HGNC Symbol;Acc:HGNC:1617] |
| Ensembl ID | ENSG00000115484 |
| Bio databases IDs | |
| Aliases | chaperonin containing TCP1 subunit 4 |
| Synonyms | 2610204B21RIK, A45, Cctd, CCT-DELTA, CCT-δ, chaperonin containing TCP1 subunit 4, SRB, T complex protein 1, delta subunit, T complex protein 1, δ subunit, TCP1 delta, TCP1 δ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCT4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- T-complex protein 1, beta subunit
- T-complex protein 1, alpha subunit
- T-complex protein 1, zeta subunit
- thermosome, various subunits, archaeal
- T-complex protein 1, eta subunit
- T-complex protein 1, delta subunit
- T-complex protein 1, gamma subunit
- protein binding
- chaperonin_like
- TCP-1/cpn60 chaperonin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- invasive breast cancer
- Wilms tumor
- Wilms tumorigenesis
- infection by Influenza A virus subtype H1N1
role in cell
- apoptosis
- cell viability
- cell death
- mitosis
- trafficking
- binding
- aggregation in
- trafficking in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- centrosome
- microtubules
- cytosol
- nucleoplasm
- synaptic vesicles
- perikaryon
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCT4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of telomerase activity
- binding of sperm to zona pellucida
- chaperone-mediated protein folding
- positive regulation of telomere maintenance via telomerase
- protein stabilization
- protein folding
Cellular Component
Where in the cell the gene product is active
- chaperonin-containing T-complex
- centrosome
- extracellular vesicular exosome
- melanosome
- cell body
- cytosol
- cell projection
- sperm protein complex
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- protein binding
- protein binding involved in protein folding
- unfolded protein binding