SLX1A Gene Summary [Human]
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) gene. [provided by RefSeq, Nov 2010]
Details
| Type | Retained Intron |
| Official Symbol | SLX1A |
| Official Name | SLX1 homolog A, structure-specific endonuclease subunit [Source:HGNC Symbol;Acc:HGNC:20922] |
| Ensembl ID | ENSG00000132207 |
| Bio databases IDs | |
| Aliases | SLX1 homolog A, structure-specific endonuclease subunit |
| Synonyms | 1110030E23Rik, 2410170E21Rik, 4833422P03Rik, GIYD1, Giyd2, LOC101060729, LOC101929864, Slx1b, SLX1 homolog A, structure-specific endonuclease subunit, SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLX1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- crossover junction endoribonuclease
- GIY-YIG nuclease domain superfamily
- GIY-YIG catalytic domain
- enzyme
- flap endonuclease
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLX1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA double-strand break processing involved in repair via single-strand annealing
- double-strand break repair via homologous recombination
- telomere maintenance via telomere lengthening
Cellular Component
Where in the cell the gene product is active
- Slx1-Slx4 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 5'-flap endonuclease activity
- protein binding
- metal ion binding
- crossover junction endodeoxyribonuclease activity