BACH1 Gene Summary [Human]
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
Details
| Type | Protein Coding |
| Official Symbol | BACH1 |
| Official Name | BTB domain and CNC homolog 1 [Source:HGNC Symbol;Acc:HGNC:935] |
| Ensembl ID | ENSG00000156273 |
| Bio databases IDs | |
| Aliases | BTB domain and CNC homolog 1 |
| Synonyms | 6230421P05RIK, BTB and CNC Homology 1, BTB and CNC homology 1, basic leucine zipper transcription factor 1, BTBD24, BTB domain and CNC homolog 1, C21ORF41, circBACH1, LOC100911490, LOC103690154 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BACH1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- BTB_POZ
- cysteine-proline dipeptide repeat motif
- Basic region leucine zipper
- heme binding domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- Broad-Complex, Tramtrack and Bric a brac
- double-stranded DNA binding
- BTB/POZ domain
- bZIP
- transcription factor activity
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the BACH1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- heart failure
- breast cancer
- epithelial cancer
- obesity
- metastasis
- refractive error
- hepatocellular carcinoma
- liver cancer
- diabetes mellitus
role in cell
- cell viability
- apoptosis
- expression in
- production in
- migration
- growth
- activation in
- invasion by
- phosphorylation in
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BACH1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- DNA repair
- regulation of transcription, DNA-dependent
- regulation of metabolic process
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- heme binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity