PSME4 Gene Summary [Human]
Predicted to enable lysine-acetylated histone binding activity; peptidase activator activity; and proteasome binding activity. Predicted to be involved in DNA repair; proteasomal ubiquitin-independent protein catabolic process; and spermatogenesis, exchange of chromosomal proteins. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PSME4 |
| Official Name | proteasome activator subunit 4 [Source:HGNC Symbol;Acc:HGNC:20635] |
| Ensembl ID | ENSG00000068878 |
| Bio databases IDs | |
| Aliases | proteasome activator subunit 4 |
| Synonyms | Blm10, hBlm10, KIAA0077, mBlm10, mKIAA0077, PA200, proteasome activator subunit 4, proteasome (prosome, macropain) activator subunit 4, TEMO |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSME4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- Proteasome-substrate-size regulator, mid region
- Domain of unknown function (DUF3437)
- protein binding
- protease activator
Pathways
Biological processes and signaling networks where the PSME4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- asthenozoospermia
- squamous-cell carcinoma
- squamous cell cancer
- chromosomal instability
- teratozoospermia
regulates
- core histone
role in cell
- survival
- apoptosis
- abnormal morphology
- condensation
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSME4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- sperm chromatin condensation
- response to DNA damage stimulus
- proteasomal ubiquitin-independent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- peptidase activator activity
- proteasome binding
- protein binding
- histone acetyl-lysine binding