Slx1b Gene Summary [Mouse]
Predicted to enable 5'-flap endonuclease activity and crossover junction DNA endonuclease activity. Involved in positive regulation of t-circle formation and t-circle formation. Predicted to be located in nucleoplasm. Predicted to be part of Slx1-Slx4 complex. Used to study Fanconi-like syndrome. Orthologous to human SLX1A (SLX1 homolog A, structure-specific endonuclease subunit) and SLX1B (SLX1 homolog B, structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slx1b |
| Official Name | SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1915220] |
| Ensembl ID | ENSMUSG00000059772 |
| Bio databases IDs | |
| Aliases | SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) |
| Synonyms | 1110030E23Rik, 2410170E21Rik, 4833422P03Rik, GIYD1, Giyd2, LOC101060729, LOC101929864, Slx1b, SLX1 homolog A, structure-specific endonuclease subunit, SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slx1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- crossover junction endoribonuclease
- GIY-YIG nuclease domain superfamily
- GIY-YIG catalytic domain
- enzyme
- flap endonuclease
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slx1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA double-strand break processing involved in repair via single-strand annealing
- double-strand break repair via homologous recombination
- telomere maintenance via telomere lengthening
Cellular Component
Where in the cell the gene product is active
- Slx1-Slx4 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 5'-flap endonuclease activity
- protein binding
- metal ion binding
- crossover junction endodeoxyribonuclease activity