Polr3f Gene Summary [Mouse]
Predicted to enable 4 iron, 4 sulfur cluster binding activity and double-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in immunodeficiency 101. Orthologous to human POLR3F (RNA polymerase III subunit F). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polr3f |
| Official Name | polymerase (RNA) III (DNA directed) polypeptide F [Source:MGI Symbol;Acc:MGI:1924086] |
| Ensembl ID | ENSMUSG00000027427 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) III (DNA directed) polypeptide F |
| Synonyms | 2810411G20Rik, 3010019O03RIK, 3110032A07Rik, C34, IMD101, polymerase (RNA) III (DNA directed) polypeptide F, RNA polymerase III subunit F, RPC39, RPC6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr3f often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- double-stranded DNA binding
- RNA polymerase Rpc34 subunit
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr3f gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of innate immune response
- transcription from RNA polymerase III promoter
- innate immune response
- positive regulation of interferon-beta production
- defense response to virus
- regulation of transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA-directed RNA polymerase activity
- protein binding
- double-stranded DNA binding
- 4 iron, 4 sulfur cluster binding