SSTR4 Gene Summary [Human]
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SSTR4 |
| Official Name | somatostatin receptor 4 [Source:HGNC Symbol;Acc:HGNC:11333] |
| Ensembl ID | ENSG00000132671 |
| Bio databases IDs | |
| Aliases | somatostatin receptor 4 |
| Synonyms | Smstr4, somatostatin receptor 4, SS-4-R, SST4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SSTR4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- somatostatin receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the SSTR4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- breast cancer
- prostate cancer
- obesity
- ovarian cancer
- fallopian tube cancer
- hepatorenal syndrome
- metastatic malignant gastrointestinal neuroendocrine tumor
- functional neuroendocrine carcinoma
- chemotherapy-induced diarrhea
role in cell
- proliferation
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- synapse
- membrane processes
- perikaryon
- dendrites
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SSTR4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of arachidonic acid secretion
- neuropeptide signaling pathway
- forebrain development
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- negative regulation of cell proliferation
- cellular response to glucocorticoid stimulus
- positive regulation of ERK1 and ERK2 cascade
- cell migration
Cellular Component
Where in the cell the gene product is active
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neuropeptide binding
- protein binding
- somatostatin receptor activity