NMUR2 Gene Summary [Human]
This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NMUR2 |
| Official Name | neuromedin U receptor 2 [Source:HGNC Symbol;Acc:HGNC:16454] |
| Ensembl ID | ENSG00000132911 |
| Bio databases IDs | |
| Aliases | neuromedin U receptor 2 |
| Synonyms | FM-4, neuromedin U receptor 2, NMU2R, TGR-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NMUR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- GTP binding
- Cholecystokinin A receptor, N-terminal
- Neuromedin-U receptor 2, C-terminal
- neuromedin U receptor
- neuropeptide receptor
- intracellular calcium activated chloride channel
- neuromedin U binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the NMUR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NMUR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of calcium-mediated signaling
- response to pain
- neuropeptide signaling pathway
- grooming behavior
- central nervous system development
- arachidonic acid secretion
- cell-cell signaling
- feeding behavior
- phospholipase C-activating G-protein coupled receptor signaling pathway
- reduction of food intake in response to dietary excess
- regulation of smooth muscle contraction
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- G-protein coupled receptor activity
- protein binding
- neuromedin U binding
- intracellular calcium activated chloride channel activity
- neuropeptide receptor activity
- neuromedin U receptor activity