IGHA2 Gene Summary [Human]
Contributes to immunoglobulin receptor binding activity. Involved in antibacterial humoral response; glomerular filtration; and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Immunoglobulin Constant Gene |
| Official Symbol | IGHA2 |
| Official Name | immunoglobulin heavy constant alpha 2 (A2m marker) [Source:HGNC Symbol;Acc:HGNC:5479] |
| Ensembl ID | ENSG00000211890 |
| Bio databases IDs | |
| Aliases | immunoglobulin heavy constant alpha 2 (A2m marker) |
| Synonyms | A2M, immunoglobulin heavy constant alpha 2 (A2m marker), immunoglobulin heavy constant α 2 (A2m marker) |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGHA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- antigen binding
- receptor binding
- Fc domain
Pathways
Biological processes and signaling networks where the IGHA2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- B Cell Development
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- FcγRIIB Signaling in B Lymphocytes
- IL-15 Signaling
- p70S6K Signaling
- PI3K Signaling in B Lymphocytes
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGHA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- positive regulation of respiratory burst
- complement activation, classical pathway
- glomerular filtration
- adaptive immune response
- antibacterial humoral response
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- secretory IgA immunoglobulin complex
- immunoglobulin complex, circulating
- blood microparticle
- secretory dimeric IgA immunoglobulin complex
- extracellular region
- monomeric IgA immunoglobulin complex
- IgA immunoglobulin complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- antigen binding
- immunoglobulin receptor binding