Nmur2 Gene Summary [Mouse]
Enables neuropeptide receptor activity. Acts upstream of or within several processes, including grooming behavior; neuropeptide signaling pathway; and reduction of food intake in response to dietary excess. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human NMUR2 (neuromedin U receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nmur2 |
| Official Name | neuromedin U receptor 2 [Source:MGI Symbol;Acc:MGI:2441765] |
| Ensembl ID | ENSMUSG00000037393 |
| Bio databases IDs | |
| Aliases | neuromedin U receptor 2 |
| Synonyms | FM-4, neuromedin U receptor 2, NMU2R, TGR-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nmur2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- GTP binding
- Cholecystokinin A receptor, N-terminal
- Neuromedin-U receptor 2, C-terminal
- neuromedin U receptor
- neuropeptide receptor
- intracellular calcium activated chloride channel
- neuromedin U binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Nmur2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nmur2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of calcium-mediated signaling
- response to pain
- neuropeptide signaling pathway
- grooming behavior
- central nervous system development
- arachidonic acid secretion
- cell-cell signaling
- feeding behavior
- phospholipase C-activating G-protein coupled receptor signaling pathway
- reduction of food intake in response to dietary excess
- regulation of smooth muscle contraction
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- G-protein coupled receptor activity
- protein binding
- neuromedin U binding
- intracellular calcium activated chloride channel activity
- neuropeptide receptor activity
- neuromedin U receptor activity