WDR74 Gene Summary [Human]
Involved in rRNA processing and ribosomal large subunit biogenesis. Located in nucleoplasm. Colocalizes with nuclear exosome (RNase complex) and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | WDR74 |
| Official Name | WD repeat domain 74 [Source:HGNC Symbol;Acc:HGNC:25529] |
| Ensembl ID | ENSG00000133316 |
| Bio databases IDs | |
| Aliases | WD repeat domain 74 |
| Synonyms | 5730436H21Rik, FLJ10439, LOC686449, Nsa1, Sumo, WD repeat domain 74 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WDR74 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- Ribosome biogenesis protein Nsa1 and similar proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- liver cancer
- chronic lymphocytic leukemia
- lung adenocarcinoma
- lung adenocarcinoma formation
- head and neck cancer
- bladder cancer
- melanoma
- melanoma cancer
- squamous cell lung cancer
regulates
- ribosomal large subunit
role in cell
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WDR74 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA metabolic process
- ribosomal large subunit biogenesis
- blastocyst formation
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- nuclear exosome (RNase complex)
- nucleus
- nucleolus
- nucleoplasm
- preribosome, large subunit precursor
Molecular Function
What the gene product does at the molecular level
- protein binding