BUB1B Gene Summary [Human]
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | BUB1B |
| Official Name | BUB1 mitotic checkpoint serine/threonine kinase B [Source:HGNC Symbol;Acc:HGNC:1149] |
| Ensembl ID | ENSG00000156970 |
| Bio databases IDs | |
| Aliases | BUB1 mitotic checkpoint serine/threonine kinase B |
| Synonyms | Bub1A, BUB1beta, BUB1B, mitotic checkpoint serine/threonine kinase, BUB1 mitotic checkpoint serine/threonine kinase B, BUBR1, hBUBR1, MAD3, MAD3L, MVA1, SSK1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BUB1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- protein kinase
- Mad3/BUB1 homology region 1
- destruction box
- Protein Kinases, catalytic domain
- BUB3 binding domain
- Phe box
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- small cell lung cancer
- tumorigenesis
- lung squamous cell carcinoma
- squamous cell lung cancer
- liver cancer
- epithelial cancer
- glomerulosclerosis
- organismal death
role in cell
- cell death
- accumulation
- apoptosis
- cell viability
- quantity
- growth
- survival
- missegregation
- senescence
- spindle checkpoint
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Cytoplasm
- perinuclear region
- basal bodies
- cytosol
- chromosome
- mitotic spindle
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BUB1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- cell division
- apoptotic process
- mitotic metaphase/anaphase transition
- meiotic sister chromatid cohesion, centromeric
- protein localization to chromosome, centromeric region
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- anaphase-promoting complex
- spindle
- cytosol
- mitotic checkpoint complex
- kinetochore
- condensed chromosome outer kinetochore
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity