RCHY1 Gene Summary [Human]
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]
Details
| Type | Protein Coding |
| Official Symbol | RCHY1 |
| Official Name | ring finger and CHY zinc finger domain containing 1 [Source:HGNC Symbol;Acc:HGNC:17479] |
| Ensembl ID | ENSG00000163743 |
| Bio databases IDs | |
| Aliases | ring finger and CHY zinc finger domain containing 1, androgen-receptor N-terminal-interacting protein, p53-induced protein with a RING-H2 domain, zinc finger, CHY-type |
| Synonyms | ARNIP, CHIMP, PIRH2, PRO1996, ring finger and CHY zinc finger domain containing 1, RNF199, ZCHY, Zfp363, ZNF363 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RCHY1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- enzyme
- p53 binding
- Ring finger domain
- protein binding
- receptor binding
- zinc ion binding
- CHY zinc finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- protein homodimerization
- zinc finger domain
- p53-binding domain
- zinc-ribbon
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- prostate cancer
- neonatal late-onset sepsis
role in cell
- differentiation
- degradation in
- expression in
- proliferation
- cell death
- growth
- recruitment in
- mono-ubiquitination in
- survival
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RCHY1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rescue of stalled ribosome
- positive regulation of protein ubiquitination
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- error-free translesion synthesis
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- nuclear speck
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- p53 binding
- zinc ion binding
- protein homodimerization activity
- protein binding