AGTPBP1 Gene Summary [Human]
NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.[supplied by OMIM, Jul 2002]
Details
| Type | Protein Coding |
| Official Symbol | AGTPBP1 |
| Official Name | ATP/GTP binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17258] |
| Ensembl ID | ENSG00000135049 |
| Bio databases IDs | |
| Aliases | ATP/GTP binding protein 1, ATP/GTP binding carboxypeptidase 1, cytosolic carboxypeptidase 1, tubulinyl-Tyr carboxypeptidase, carboxypeptidase-tubulin, tyrosine carboxypeptidase, soluble carboxypeptidase |
| Synonyms | 1700020N17Rik, 2310001G17RIK, 2900054O13Rik, 4930445M19Rik, 5730402G09RIK, atms, ATP/GTP binding carboxypeptidase 1, ATP/GTP binding protein 1, CCP1, CONDCA, KIAA1035, LOC102724057, nmf243, NNA1, pcd, RP11 213G22 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGTPBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zn_pept domain
- tubulin binding
- peptidase
- metallocarboxypeptidase
- protein binding
- Cytosolic carboxypeptidase N-terminal domain
- M14 family of metallocarboxypeptidases and related proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- childhood-onset neurodegeneration with cerebellar atrophy
- breast carcinoma
- papillary thyroid cancer
- neurodevelopmental disorder with cerebellar atrophy and with or without seizures
regulated by
- ADAM10
- heavy metal
- benzo(a)pyrene
- sulindac sulfide
- zeaxanthin dipalmitate
role in cell
- cell death
- expression in
- production in
- migration
- proliferation
- differentiation
- survival
- invasion by
- degeneration
- production
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- cilia
- Plasma Membrane
- basal bodies
- centrosome
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGTPBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- cerebellar Purkinje cell differentiation
- retina development in camera-type eye
- negative regulation of cell proliferation
- neuromuscular process
- central nervous system neuron development
- olfactory bulb development
- mitochondrion organization
- adult walking behavior
- eye photoreceptor cell differentiation
- protein deglutamylation
- C-terminal protein deglutamylation
- proteolysis
- protein side chain deglutamylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- zinc ion binding
- metallocarboxypeptidase activity