Agtpbp1 Gene Summary [Rat]
Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Predicted to be involved in mitochondrion organization; nervous system development; and protein deglutamylation. Predicted to act upstream of or within several processes, including adult walking behavior; axonal transport of mitochondrion; and central nervous system neuron differentiation. Predicted to be located in several cellular components, including microtubule organizing center; mitochondrion; and nucleoplasm. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Orthologous to human AGTPBP1 (ATP/GTP binding carboxypeptidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agtpbp1 |
| Official Name | ATP/GTP binding protein 1 [Source:RGD Symbol;Acc:1306307] |
| Ensembl ID | ENSRNOG00000018651 |
| Bio databases IDs | |
| Aliases | ATP/GTP binding protein 1 |
| Synonyms | 1700020N17Rik, 2310001G17RIK, 2900054O13Rik, 4930445M19Rik, 5730402G09RIK, atms, ATP/GTP binding carboxypeptidase 1, ATP/GTP binding protein 1, CCP1, CONDCA, KIAA1035, LOC102724057, nmf243, NNA1, pcd, RP11 213G22 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Agtpbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zn_pept domain
- tubulin binding
- peptidase
- metallocarboxypeptidase
- protein binding
- Cytosolic carboxypeptidase N-terminal domain
- M14 family of metallocarboxypeptidases and related proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- childhood-onset neurodegeneration with cerebellar atrophy
- breast carcinoma
- papillary thyroid cancer
- neurodevelopmental disorder with cerebellar atrophy and with or without seizures
regulated by
- ADAM10
- heavy metal
- benzo(a)pyrene
- sulindac sulfide
- zeaxanthin dipalmitate
role in cell
- cell death
- expression in
- production in
- migration
- proliferation
- differentiation
- survival
- invasion by
- degeneration
- production
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- cilia
- Plasma Membrane
- basal bodies
- centrosome
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Agtpbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- cerebellar Purkinje cell differentiation
- retina development in camera-type eye
- negative regulation of cell proliferation
- neuromuscular process
- central nervous system neuron development
- olfactory bulb development
- mitochondrion organization
- adult walking behavior
- eye photoreceptor cell differentiation
- protein deglutamylation
- C-terminal protein deglutamylation
- proteolysis
- protein side chain deglutamylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- zinc ion binding
- metallocarboxypeptidase activity