Agtpbp1 Gene Summary [Mouse]
Enables metallocarboxypeptidase activity and tubulin binding activity. Involved in several processes, including nervous system development; neuromuscular process; and protein deglutamylation. Acts upstream of or within several processes, including adult walking behavior; axonal transport of mitochondrion; and central nervous system development. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; liver; and retina. Used to study retinitis pigmentosa. Orthologous to human AGTPBP1 (ATP/GTP binding carboxypeptidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agtpbp1 |
| Official Name | ATP/GTP binding protein 1 [Source:MGI Symbol;Acc:MGI:2159437] |
| Ensembl ID | ENSMUSG00000021557 |
| Bio databases IDs | |
| Aliases | ATP/GTP binding protein 1 |
| Synonyms | 1700020N17Rik, 2310001G17RIK, 2900054O13Rik, 4930445M19Rik, 5730402G09RIK, atms, ATP/GTP binding carboxypeptidase 1, ATP/GTP binding protein 1, CCP1, CONDCA, KIAA1035, LOC102724057, nmf243, NNA1, pcd, RP11 213G22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Agtpbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zn_pept domain
- tubulin binding
- peptidase
- metallocarboxypeptidase
- protein binding
- Cytosolic carboxypeptidase N-terminal domain
- M14 family of metallocarboxypeptidases and related proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- ADAM10
- heavy metal
- benzo(a)pyrene
- sulindac sulfide
- zeaxanthin dipalmitate
disease
- neoplasia
- colorectal cancer
- childhood-onset neurodegeneration with cerebellar atrophy
- breast carcinoma
- papillary thyroid cancer
- neurodevelopmental disorder with cerebellar atrophy and with or without seizures
phenotypes
- Purkinje cell degeneration
- abnormal Purkinje cell dendrite morphology
- abnormal T cell differentiation
- abnormal T cell physiology
- abnormal T cell subpopulation ratio
- abnormal auditory brainstem response
- abnormal cerebellar Purkinje cell layer
- abnormal cerebellar granule layer morphology
- abnormal cochlear VIII nucleus morphology
- abnormal cone electrophysiology
- abnormal eye electrophysiology
- abnormal lymphocyte cell number
- abnormal male germ cell morphology
- abnormal mitral cell morphology
- abnormal motor coordination/ balance
- abnormal olfactory bulb morphology
- abnormal photoreceptor connecting cilium morphology
- abnormal photoreceptor inner segment morphology
- abnormal photoreceptor outer segment morphology
- abnormal retinal inner plexiform layer morphology
- abnormal retinal layer morphology
- abnormal retinal outer nuclear layer morphology
- abnormal retinal photoreceptor layer morphology
- abnormal retinal rod cell morphology
- abnormal rod electrophysiology
- abnormal spleen morphology
- abnormal thalamus morphology
- abnormal ventral spinal root morphology
- asthenozoospermia
- ataxia
- azoospermia
- decreased B cell number
- decreased Purkinje cell number
- decreased activated sperm motility
- decreased amacrine cell number
- decreased body size
- decreased body weight
- decreased litter size
- decreased skeletal muscle fiber size
- decreased spleen weight
- enlarged hippocampus
- impaired coordination
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- infertility
- male infertility
- oligozoospermia
- paraparesis
- reduced female fertility
- reduced fertility
- reduced male fertility
- retinal degeneration
- retinal photoreceptor degeneration
- small cerebellum
- spleen hypoplasia
- teratozoospermia
- testicular atrophy
- thin retinal outer nuclear layer
- tremors
role in cell
- cell death
- expression in
- production in
- migration
- proliferation
- differentiation
- survival
- invasion by
- degeneration
- production
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- cilia
- Plasma Membrane
- basal bodies
- centrosome
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Agtpbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- cerebellar Purkinje cell differentiation
- retina development in camera-type eye
- negative regulation of cell proliferation
- neuromuscular process
- central nervous system neuron development
- olfactory bulb development
- mitochondrion organization
- adult walking behavior
- eye photoreceptor cell differentiation
- protein deglutamylation
- C-terminal protein deglutamylation
- proteolysis
- protein side chain deglutamylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- zinc ion binding
- metallocarboxypeptidase activity