SMC4 Gene Summary [Human]
This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016]
Details
| Type | Protein Coding |
| Official Symbol | SMC4 |
| Official Name | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] |
| Ensembl ID | ENSG00000113810 |
| Bio databases IDs | |
| Aliases | structural maintenance of chromosomes 4 |
| Synonyms | 2500002A22Rik, CAP-C, DKFZP434F205, SMC4L1, structural maintenance of chromosomes 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SMC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, primarily archaeal type
- SMC proteins Flexible Hinge Domain
- exonuclease SbcC
- ATP binding
- helix-rich Mycoplasma protein
- chromatin binding
- protein binding
- Laminin Domain I
- AAA domain
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- single-stranded DNA binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- serous ovarian adenocarcinoma
- serous ovarian cancer
- Hutchinson-Gilford progeria syndrome
- prostate cancer
- major depression
- androgenic alopecia
- primary ovarian cancer
role in cell
- proliferation
- survival
- cell viability
- organization
- condensation
- segregation
- alignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- nuclear scaffolds
- nuclear speckles
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SMC4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of chromosome segregation
- meiotic chromosome condensation
- mitotic chromosome condensation
- kinetochore organization
- meiotic chromosome segregation
- mitotic sister chromatid segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- cytosol
- chromosome, centromeric region
- condensin complex
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- chromatin binding
- single-stranded DNA binding