FBXO21 Gene Summary [Human]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FBXO21 |
| Official Name | F-box protein 21 [Source:HGNC Symbol;Acc:HGNC:13592] |
| Ensembl ID | ENSG00000135108 |
| Bio databases IDs | |
| Aliases | F-box protein 21 |
| Synonyms | 2810425J22Rik, F-box protein 21, FBX21 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXO21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transglutaminase-like superfamily
- F-box domain
- F-box domain superfamily
- Hemimethylated DNA-binding protein YccV like
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- systemic autoimmune syndrome
- insomnia
- coronary artery disease
- acute myeloid leukemia
- infection by HIV-1
regulates
role in cell
- apoptosis
- differentiation
- degradation in
- polyubiquitination in
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXO21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- DNA binding
- protein binding