HRK Gene Summary [Human]
This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | HRK |
| Official Name | harakiri, BCL2 interacting protein [Source:HGNC Symbol;Acc:HGNC:5185] |
| Ensembl ID | ENSG00000135116 |
| Bio databases IDs | |
| Aliases | harakiri, BCL2 interacting protein, death protein 5 |
| Synonyms | AI838259, BCL2 INTERACTING, Bid3, DP5, HARAKIRI, harakiri, BCL2 interacting protein, harakiri, BCL2 interacting protein (contains only BH3 domain), LOC283454 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HRK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2 homology 3 domain
- Activator of apoptosis harakiri
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- cancer
- Alzheimer disease
- carcinoma in situ
- epithelial cancer in situ
- melanoma cancer
- amyotrophic lateral sclerosis
role in cell
- migration
- phosphorylation in
- cell death
- apoptosis
- proliferation
- quantity
- killing
- growth
- invasion by
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HRK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- positive regulation of release of cytochrome c from mitochondria
- positive regulation of apoptotic process
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding