BAG1 Gene Summary [Human]
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]
Details
| Type | Processed Transcript |
| Official Symbol | BAG1 |
| Official Name | BAG cochaperone 1 [Source:HGNC Symbol;Acc:HGNC:937] |
| Ensembl ID | ENSG00000107262 |
| Bio databases IDs | |
| Aliases | BAG cochaperone 1 |
| Synonyms | BAG cochaperone 1, BCL2-associated athanogene 1, HAP, RAP46 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BAG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- hexapeptide domain
- BAG domains, present in regulator of Hsp70 proteins
- alpha helix
- protein binding
- ubiquitin-like domain
- acidic domain
- hsp70 binding domain
- Ubiquitin family
- adenyl-nucleotide exchange factor
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- BAG domain
Pathways
Biological processes and signaling networks where the BAG1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- COVID-19
- hypoplasia
- breast carcinoma
- Alzheimer disease
- squamous cell cancer of the oral cavity
- acute myeloid leukemia
- mucoepidermoid carcinoma
- acinar-cell carcinoma
- salivary duct carcinoma
role in cell
- cell viability
- expression in
- phosphorylation in
- proliferation
- activation in
- cell death
- apoptosis
- migration
- outgrowth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear body
- perinuclear region
- Nucleus
- Plasma Membrane
- vesicles
- Mitochondria
- cytosol
- nucleoplasm
- perinuclear space
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BAG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smooth muscle cell apoptotic process
- negative regulation of apoptotic process
- apoptotic process
- chaperone mediated protein folding requiring cofactor
- cell surface receptor signaling pathway
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- chaperone binding
- adenyl-nucleotide exchange factor activity