STRN Gene Summary [Human]
Enables armadillo repeat domain binding activity; estrogen receptor binding activity; and protein phosphatase 2A binding activity. Involved in Wnt signaling pathway and negative regulation of cell population proliferation. Located in bicellular tight junction. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | STRN |
| Official Name | striatin [Source:HGNC Symbol;Acc:HGNC:11424] |
| Ensembl ID | ENSG00000115808 |
| Bio databases IDs | |
| Aliases | striatin, protein phosphatase 2 regulatory subunit B'''alpha |
| Synonyms | D130055P19, PPP2R6A, PR110, SG2NA, Striatin, striatin, calmodulin binding protein, STRN1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STRN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- WD40 repeats
- calmodulin binding
- protein phosphatase binding
- WD domain, G-beta repeat
- WD40
- protein domain specific binding
- protein binding
- estrogen receptor binding
- Striatin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial basal cell carcinoma
- epithelial cancer
- schizophrenia
- hepatocellular carcinoma
- liver cancer
- metabolic syndrome X
- Waldenström macroglobulinemia
- myeloid/lymphoid neoplasm with eosinophilia
- hematological neoplasia
- heart failure
role in cell
- expression in
- proliferation
- migration
- development
- morphology
- polarization
- migration by
- invasion by
- polarization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- perinuclear region
- postsynaptic region
- cellular membrane
- Plasma Membrane
- cytosol
- postsynaptic membrane
- dendritic spines
- tight junctions
- perikaryon
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STRN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- locomotory behavior
- negative regulation of cell proliferation
- tight junction assembly
- Wnt receptor signaling pathway
- dendrite development
Cellular Component
Where in the cell the gene product is active
- dendrite
- postsynaptic density
- tight junction
- postsynaptic membrane
- dendritic spine
- membrane
- cytosol
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- armadillo repeat domain binding
- estrogen receptor binding
- protein phosphatase 2A binding