CHRNA9 Gene Summary [Human]
This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | CHRNA9 |
| Official Name | cholinergic receptor nicotinic alpha 9 subunit [Source:HGNC Symbol;Acc:HGNC:14079] |
| Ensembl ID | ENSG00000174343 |
| Bio databases IDs | |
| Aliases | cholinergic receptor nicotinic alpha 9 subunit, acetylcholine receptor, nicotinic, alpha 9 (neuronal) |
| Synonyms | 2410015I05Rik, Acra9, cholinergic receptor nicotinic alpha 9 subunit, cholinergic receptor, nicotinic, alpha polypeptide 9, cholinergic receptor nicotinic α 9 subunit, cholinergic receptor, nicotinic, α polypeptide 9, EG666827, Gm8311, HSA243342, NACHRA9, Nachr α 9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHRNA9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- LGIC_ECD
- neurotransmitter receptor
- Neurotransmitter-gated ion-channel transmembrane region
- channel/pore class transporter
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- protein binding
- extracellular ligand-gated ion channel
- Cation transporter family protein
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the CHRNA9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- postoperative pain
- COVID-19
- Alzheimer disease
- HIV infection
- morbid obesity
- hemodynamic instability
- insomnia
- psychological disorder
- neoplastic cell transformation
- acute respiratory distress syndrome
role in cell
- proliferation
- number
- phosphorylation in
- depolarization
- innervation
- function
- loss
- infiltration by
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- synaptic membrane
- synaptic vesicles
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHRNA9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- regulation of membrane potential
- ion transmembrane transport
- inner ear morphogenesis
- calcium ion transmembrane transport
- response to auditory stimulus
- synaptic transmission
- membrane depolarization
- detection of mechanical stimulus involved in sensory perception of sound
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- synapse
- acetylcholine-gated channel complex
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- acetylcholine-gated cation channel activity
- calcium channel activity